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Although citalopram (a wellbutrin and alcohol use who makes wellbutrin how much wellbutrin can you take a day what will SSRI) is not primarily metabolized by CYP2D6, in one study (a 3-period, sequential-treatment, crossover study in 30 healthy volunteers), bupropion increased the Cmax and AUC of citalopram by 30% and 40% respectively .
Citalopram did not significantly alter the pharmacokinetics of common side effects of wellbutrin wellbutrin side effects children wellbutrin starting dose brand bupropion in this study .
In an open-label, two-phase, sequential study of 64 healthy volunteers, ritonavir (100 mg twice daily or 600 mg twice daily) or ritonavir 100 mg plus average dose of wellbutrin wellbutrin how long until it works benefits of taking wellbutrin lopinavir 400 mg (Kaletra®) twice daily reduced the exposure of bupropion (150-300 mg daily) and its major metabolites in a dose dependent manner by approximately 20 to 80% .
Similarly, efavirenz wellbutrin 600 mg once daily for two weeks reduced the exposure of a single oral 150 mg dose of bupropion by approximately 55% in 13 healthy volunteers (18-55 years of age) .
This effect of ritonavir/Kaletra® and efavirenz is thought to be due to the induction of bupropion metabolism and can be clinically wellbutrin s wellbutrin 450 mg side effects wellbutrin side effects pregnancy how wellbutrin works significant .
Patients receiving any of these drugs with bupropion may need increased doses of when does wellbutrin start working wellbutrin causing depression bupropion wellbutrin xl reviews on bupropion but the maximum recommended daily dose of bupropion should not be exceeded .
The effects of bupropion on the PK parameters of ritonavir/Kaletra® and efavirenz have not been wellbutrin studied .

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